Thermo Fisher Scientific proMPO Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: proMPO

Target Information

Myeloperoxidase (MPO) is a hemoprotein abundantly expressed in neutrophils and secreted during their activation. It exists as a covalently bound tetrameric complex of two glycosylated alpha chains (59–64 kDa) and two unglycosylated beta chains (~14 kDa), with a total molecular weight of ~150 kDa and a theoretical pI of 9.2.

MPO is a major target of anti-neutrophil cytoplasm antibodies (ANCA), which are markers for systemic vasculitis such as periarteriitis nodosa, microscopic polyarteriitis, and Churg-Strauss syndrome. Low to moderate levels of anti-MPO autoantibodies are also reported in rheumatoid arthritis. MPO is implicated in cardiovascular disease progression and possesses strong proinflammatory properties contributing to tissue injury. It plays a key role in the host defense system of polymorphonuclear leukocytes, catalyzing the production of hypohalous acids (primarily hypochlorous acid) and other toxic intermediates that enhance microbicidal activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.