Thermo Fisher Scientific proMPO Polyclonal Antibody
Human proMPO를 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC에 적합합니다. 동결건조 형태로 제공되며, 4°C 단기 또는 -20°C 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human proMPO conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: proMPO
Target Information
Myeloperoxidase (MPO) is a hemoprotein abundantly expressed in neutrophils and secreted during their activation. It exists as a covalently bound tetrameric complex of two glycosylated alpha chains (59–64 kDa) and two unglycosylated beta chains (~14 kDa), with a total molecular weight of ~150 kDa and a theoretical pI of 9.2.
MPO is a major target of anti-neutrophil cytoplasm antibodies (ANCA), which are markers for systemic vasculitis such as periarteriitis nodosa, microscopic polyarteriitis, and Churg-Strauss syndrome. Low to moderate levels of anti-MPO autoantibodies are also reported in rheumatoid arthritis. MPO is implicated in cardiovascular disease progression and possesses strong proinflammatory properties contributing to tissue injury. It plays a key role in the host defense system of polymorphonuclear leukocytes, catalyzing the production of hypohalous acids (primarily hypochlorous acid) and other toxic intermediates that enhance microbicidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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