Thermo Fisher Scientific Phospho-Bcl-2 (Ser70) Polyclonal Antibody
인간 BCL-2 Ser70 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, IHC에 적합. 단백질 A로 정제된 액상 형태이며 1 mg/mL 농도. 세포 사멸 조절 연구 및 BCL-2 관련 암 연구에 활용 가능.
- 카탈로그번호
- 43065-100UL
- 판매단위
- pk
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence including phosphorylation site of Serine 70 (R-T-S(p)-P-L) derived from human Bcl-2 and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are characterized by their ability to dimerize, which further modulates apoptosis.
Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak play critical roles in cytochrome c release from mitochondria, initiating apoptosis. Bax exerts a pro-apoptotic effect, while constitutive expression of BCL-2 (e.g., via translocation to the Ig heavy chain locus) is associated with follicular lymphoma.
In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2 differ in their C-terminal ends. Overexpression of BCL-2 has been linked to cancers such as B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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