Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3D9), TrueMAB
Human PIK3C2A 단백질을 인식하는 mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. Affinity chromatography로 정제된 액상형 제품이며, PBS/BSA/glycerol buffer에 보존. 세포 신호전달 및 인슐린 반응 연구용으로 적합.
- 카탈로그번호
- TA801694
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D9 |
| Immunogen | Human recombinant protein fragment (aa 230–560 of human PIK3C2A) produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Although less studied than Class I PI3 kinases, Class II enzymes are involved in receptor-mediated processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases are key regulators in pathways affecting cell proliferation, transformation, survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, typical of Class II PI3-kinases. The C2 domain mediates calcium-dependent phospholipid binding and protein-protein interactions.
This protein’s PI3-kinase activity is not inhibited by nanomolar levels of wortmannin and can be activated by insulin, suggesting a role in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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