Thermo Fisher Scientific CD44 Monoclonal Antibody (MEM-85), FITC
인간 CD44 항원에 특이적인 FITC 결합 단클론 항체로, Flow Cytometry에 적합. 세포 표면 및 용해형 CD44 검출 가능. PBS/BSA 완충액에 보관하며 4°C 암소에서 안정적. 다양한 형광 표지 형식으로 제공.
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Thermo Fisher Scientific CD44 Monoclonal Antibody (MEM-85), FITC
Applications and Tested Dilution
- Flow Cytometry (Flow): 20 µL per 100 µL whole blood or 10⁶ cells
- Miscellaneous PubMed (Misc): -
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-85 |
| Immunogen | Leucocytes from a patient suffering from LGL-type leukemia |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072383 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- APC
- Biotin
- PE
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular antigen of both cell surface-expressed and soluble forms of CD44 antigen (Phagocyte glycoprotein 1), an 80–95 kDa transmembrane glycoprotein of the hyaladherin family. It is expressed on most cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.), and is negative on platelets and hepatocytes.
Target Information
CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast.
Several isoforms exist, including the predominant CD44H isoform detected in many normal tissues. CD44 acts as a receptor for hyaluronic acid (HA) and is involved in:
- Cell-cell interactions
- Cell adhesion and migration
- Lymphocyte activation, recirculation, and homing
CD44 expression is often up-regulated in certain carcinomas and may be associated with metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Alternative splicing produces many functionally distinct isoforms, contributing to CD44’s structural and functional diversity. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be related to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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