Thermo Fisher Scientific GPR26 Polyclonal Antibody
GPR26 단백질을 검출하는 토끼 폴리클로날 항체로, 인간 시료에서 사용 가능. IHC(P) 적용 가능하며 6–15 µg/mL 농도 권장. 뇌 특이적 GPCR 연구 및 비만 관련 대사 연구에 활용. 액상 형태로 제공되며 4°C 또는 -20°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 6–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the 3rd cytoplasmic loop of human G Protein-Coupled Receptor GPR26 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2263497 |
Product Specific Information
PA1-20409 detects G Protein-Coupled Receptor GPR26 in human samples.
Target Information
The G-protein-coupled receptor (GPCR) superfamily consists of approximately 600–1,000 members, representing the largest known class of molecular targets with proven therapeutic value.
GPR26 is a brain-specific orphan GPCR exhibiting significant constitutive activity mediated by G(s)-alpha protein, stimulating adenylate cyclase and increasing intracellular cAMP levels.
In the CNS, GPR26 shows high expression in the amygdala, hippocampus, and thalamus, with weak expression in testis. It is down-regulated in glioblastoma.
Depletion of GPR26 increases fat storage in C. elegans, and deficiency in the hypothalamus is linked to high susceptibility to obesity onset in mice.
GPR26 deficiency also leads to metabolic disorders such as glucose intolerance, hyperinsulinemia, and dyslipidemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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