Thermo Fisher Scientific GPR26 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 6–15 µg/mL

Product Specifications

Product Specific Information

PA1-20409 detects G Protein-Coupled Receptor GPR26 in human samples.

Target Information

The G-protein-coupled receptor (GPCR) superfamily consists of approximately 600–1,000 members, representing the largest known class of molecular targets with proven therapeutic value.
GPR26 is a brain-specific orphan GPCR exhibiting significant constitutive activity mediated by G(s)-alpha protein, stimulating adenylate cyclase and increasing intracellular cAMP levels.
In the CNS, GPR26 shows high expression in the amygdala, hippocampus, and thalamus, with weak expression in testis. It is down-regulated in glioblastoma.
Depletion of GPR26 increases fat storage in C. elegans, and deficiency in the hypothalamus is linked to high susceptibility to obesity onset in mice.
GPR26 deficiency also leads to metabolic disorders such as glucose intolerance, hyperinsulinemia, and dyslipidemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.