Thermo Fisher Scientific Phospho-ATR (Thr1989) Recombinant Rabbit Monoclonal Antibody (HL132)
Phospho-ATR (Thr1989) 특이성을 가진 재조합 토끼 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합. 인간 및 생쥐 반응성. 고순도 Protein A 정제, 2 mg/mL 농도. DNA 손상 반응 및 세포 주기 체크포인트 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL132 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ATR (phospho Thr1989). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890400 |
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. It phosphorylates and activates several proteins involved in the inhibition of DNA replication and mitosis, and promotes DNA repair, recombination, and apoptosis. This protein also contributes to fragile site stability and centrosome duplication. Defects in this gene cause Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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