Thermo Fisher Scientific BMI1 Monoclonal Antibody (BMI1, 2689)
BMI1 단백질을 인식하는 Mouse 모노클론 항체로, WB 및 IHC(P) 등 다양한 응용에 적합. Human 시료 반응성, Protein A/G 정제, 200 µg/mL 농도. 연구용으로만 사용 가능하며 형질 유지 관련 유전자 발현 연구에 활용.
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- 648-MSM1-P0
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BMI1, 2689 |
| Immunogen | Recombinant fragment of human BMI1 protein (around aa 142–326) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Component of the Polycomb group (PcG) multiprotein PRC1 complex, which maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development.
The PcG PRC1 complex acts via chromatin remodeling and histone modification; it mediates monoubiquitination of histone H2A at Lys-119, rendering chromatin heritably changed in its expressibility.
In the PRC1 complex, BMI1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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