Thermo Fisher Scientific CMKLR1 Polyclonal Antibody
CMKLR1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 최적화되어 있습니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 용액 내 0.1% sodium azide를 포함하며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 5 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from C-terminal cytoplasmic domain of human CMKLR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550818 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gibbon: 100%
- Marmoset, Rabbit: 95%
- Horse: 84%
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and the omega-3 fatty acid-derived molecule resolvin E1.
Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to multifunctional effects including reduction of immune responses, enhancement of adipogenesis, and angiogenesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing activation of MAPK1/3 (ERK1/2) and NF-kappa-B.
CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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