Thermo Fisher Scientific IL-4 (Interleukin-4) Monoclonal Antibody (11B11)
Mouse IL-4에 특이적인 단클론 항체로, Rat IgG1 isotype을 가짐. ICC/IF, Flow Cytometry, ELISA, Neutralization 등 다양한 응용 가능. 단백질 A/G로 정제된 액상형 항체이며, 인간과 반응하지 않음. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| ELISA | Assay-dependent |
| Neutralization | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 11B11 |
| Immunogen | Partially purified native Mouse IL-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Human.
Target Information
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells and serves as a ligand for the interleukin-4 receptor. IL-4 exhibits a broad range of biological actions. The IL-4 receptor also binds IL-13, contributing to overlapping cytokine functions. STAT6 plays a crucial role in mediating IL-4’s immune regulatory signaling.
The IL-4 gene, along with IL-3, IL-5, IL-13, and CSF2, forms a cytokine gene cluster on chromosome 5q. IL-4 is located near IL-13 and is co-regulated with IL-13 and IL-5 by long-range regulatory elements spanning approximately 120 kilobases. IL-4 delta 2 is a known splice variant of IL-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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