Thermo Fisher Scientific CD137 Monoclonal Antibody (LOB12)
CD137(4-1BB) 단백질을 인식하는 Rat IgG2a 단일클론 항체로, 마우스 시료에 반응합니다. ICC, Flow Cytometry 및 기능적 분석에 사용 가능하며, 비결합형 액상 형태로 제공됩니다. 4°C 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LOB12 |
| Immunogen | Murine CD137 human Fc fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Human.
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule expressed mainly on activated T cells.
Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling helps maintain the survival of activated T cells and CD8⁺ memory T cells, promotes clonal expansion, and modulates immune responses by regulating cytokine release and monocyte survival.
Soluble forms of CD137 may act as a negative control mechanism in certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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