Thermo Fisher Scientific MAPKBP1 Polyclonal Antibody
Human MAPKBP1 단백질을 인식하는 토끼 폴리클로날 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. NFκB 신호전달 관련 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MAPKBP1. Recombinant protein control fragment (Product # RP-94987) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2643757 |
Product Specific Information
Immunogen sequence:
EKHSPDSACS VDYSSSCLSS PEHPTEDSES TEPLSVDGIS SDLEEPAEGD EEEEEEEGGM GPYGLQEGSP QTPDQEQFLK QHFETLA
Antigen sequence identity:
- Mouse: 90%
- Rat: 90%
Target Information
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation, and apoptosis.
MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats.
Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act as an adaptor protein for NFκB (nuclear factor kappa-B) activation.
MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination.
MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15.
Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome.
Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease, and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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