Thermo Fisher Scientific MAPKBP1 Polyclonal Antibody
Human MAPKBP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol, sodium azide 포함) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MAPKBP1 (Product #RP-102575) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643758 |
Product Specific Information
Immunogen sequence:
PSSPQRASGP NRHQAPSMLS PGPALSSDSD KEGEDEGTEE ELPALPVLAK STKKALASVP SPALPRSLSH WEMSRAQ
Highest antigen sequence identity to orthologs:
- Mouse: 78%
- Rat: 76%
Target Information
MAP kinases are involved in key biological processes such as cell adhesion, differentiation, and apoptosis.
MAPKBP-1 (Mitogen-Activated Protein Kinase Binding Protein 1), also known as JNKBP-1, is a 1,514 amino acid protein containing twelve WD repeats. It is induced by TRAF2 and Tak1 and functions as an adaptor protein for NFκB activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination.
The MAPKBP1 gene is located on human chromosome 15, which contains over 700 genes and accounts for about 3% of the human genome. Genetic disorders such as Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease, and Marfan syndrome are associated with genes on this chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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