Thermo Fisher Scientific CXCR3 Polyclonal Antibody
CXCR3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human에 반응하며 mouse, rat, cow, dog, pig에서도 예측 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/BSA buffer에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 150–250 of Human CXCR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10983934 |
Product Specific Information
This antibody is predicted to react with mouse, rat, cow, dog, and pig based on sequence homology.
Target Information
This gene encodes a G protein-coupled receptor with selectivity for three chemokines: IP10 (interferon-γ-inducible 10 kDa protein), Mig (monokine induced by interferon-γ), and I-TAC (interferon-inducible T cell α-chemoattractant).
These chemokines belong to the CXC chemokine family, characterized by a single amino acid separating the first two conserved cysteine residues.
Binding of chemokines to this receptor triggers leukocyte trafficking responses such as integrin activation, cytoskeletal rearrangement, and chemotaxis.
The receptor is coupled to Gi-type G proteins and participates in rapid, transient signaling events that are desensitized via phosphorylation-dependent internalization.
It is expressed prominently in effector/memory T cells and inflamed tissues, suggesting a role in inflammatory cell recruitment.
CXCR3 is therefore a target for small-molecule antagonist development for inflammatory disease treatment.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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