Thermo Fisher Scientific KV3.2 (KCNC2) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DLGGKRLGIEDAAGLGGPDGK(C), corresponding to amino acid residues 184-204 of rat KV3.2, Intracellular, N-terminal domain if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KV3.2 (KCNC2),uniProtId:P22462-1,ncbiNodeId:10114,antigenRange:184-204,antigenLength:638,antigenImageFileName:APC-011-200UL_KV3.2_KCNC2_P22462-1_Rabbit.svg,antigenImageFileNamePDP:APC-011-200UL_KV3.2_KCNC2_P22462-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA, 5% sucrose

Contains

0.025% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels. The subunits vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits, which include the KV1, KV2, KV3, KV4 and KV9 proteins, as well as accessory subunits that modify the gating properties of the coexpressed KV subunits. KV3.2 is a multipass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. The tail of KV3.2 may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.