Thermo Fisher Scientific BCL9L Polyclonal Antibody
Thermo Fisher Scientific의 BCL9L Polyclonal Antibody는 인간 BCL9L 단백질을 인식하는 rabbit IgG 기반 항체로, WB, IHC, ICC/IF에 사용 가능. 높은 특이성과 재현성을 제공하며, Wnt 신호 경로 연구 및 암 관련 단백질 분석에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BCL9L. Recombinant protein control fragment (Product #RP-100464). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638513 |
Product Specific Information
Immunogen sequence:
MSMCHPGQMS LLGRTGVPPQ QGMVPHGLHQ GVMSPPQGLM TQQNFMLMKQ RGVGGEVYSQ PPHMLSPQGS LMGPPPQQNL MVSHPLRQRS VSLDSQMGYL PAP
Highest antigen sequence identity to orthologs:
- Mouse: 98%
- Rat: 97%
Target Information
Bcl9L, a homolog of Bcl9, was initially identified through bioinformatics screening. It is expressed in fetal brain, adult lung, eye, and prostate, as well as in several tumor types including pancreatic and prostate cancers.
Bcl9L interacts with beta-catenin, a key component of the Wnt signaling pathway, and is required for enhanced beta-catenin–TCF-mediated transcription in colorectal tumor cells, potentially by facilitating beta-catenin nuclear translocation.
Its expression correlates with high nuclear grade cancer phenotype and ErbB2/HER-2 expression in breast cancers, implying roles in multiple cancer types.
Bcl9L is also critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas, associated with tumor invasion, metastasis, and therapy resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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