Thermo Fisher Scientific C1q Monoclonal Antibody (3R9/2)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Immunohistochemistry (Frozen) (IHC (F))

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Flow Cytometry (Flow)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3R9/2

Immunogen

Globular head domain of C1q, purified from human plasma. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C1q,uniProtId:P02745-1,ncbiNodeId:9606,antigenRange:1-245,antigenLength:245,antigenImageFileName:MA1-83963_C1q_P02745-1_House_mouse.svg,antigenImageFileNamePDP:MA1-83963_C1q_P02745-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:C1q,uniProtId:P02746-1,ncbiNodeId:9606,antigenRange:1-253,antigenLength:253,antigenImageFileName:MA1-83963_C1q_P02746-1_House_mouse.svg,antigenImageFileNamePDP:MA1-83963_C1q_P02746-1_House_mouse_PDP.jpeg,sortOrder:2},{targetFamily:C1q,uniProtId:P02747-1,ncbiNodeId:9606,antigenRange:1-245,antigenLength:245,antigenImageFileName:MA1-83963_C1q_P02747-1_House_mouse.svg,antigenImageFileNamePDP:MA1-83963_C1q_P02747-1_House_mouse_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.1 mg/mL

Purification

Protein A

Storage buffer

BBS, pH 8.4

Contains

< 0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2067385

Product Specific Information

A suggested positive control for immunohistochemical applications for this product is kidney tissue from patients with streptococcal glomerulonephritis. Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).

Mouse anti human C1q antibody, clone 004-43.X (3R9/2), recognizes human complement component 1 q (C1q), a approximately 156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system.

Target Information

C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.