Thermo Fisher Scientific AGPAT2 Polyclonal Antibody
AGPAT2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 시료에 반응하며 WB 및 ELISA에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 연구용으로만 사용. LPLAT 및 LPAAT 관련 신호전달 연구에 적합.
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Thermo Fisher Scientific AGPAT2 Polyclonal Antibody
Applications
- Western Blot (WB): Assay-dependent
- ELISA: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the LPAAT protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2224947 |
Product Specific Information
A suggested positive control for this product is human brain lysate.
Target Information
Lysophospholipid acyltransferases (LPLATs) catalyze the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids. These enzymes play a crucial role in the synthesis of structural membrane components and are involved in cellular signaling responses to cytokines, growth factors, and other agonists.
Signaling through the interleukin 1 receptor in human mesangial and EL-4 cells activates lysophosphatidic acid acyltransferase (LPAAT), leading to the generation of unsaturated phosphatidic acid species essential for diacylglycerol and interleukin 1 signaling.
LPLATs also contribute to interleukin 2 synthesis in T cells, where activation via anti-CD3 stimulation increases incorporation of polyunsaturated fatty acids into phosphatidylcholine through lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for sustained activation and translocation of protein kinase C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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