Thermo Fisher Scientific NXF3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SREPYKDIGK MSLPSGHTTG HTDQVVQRRA RCWDIYQRRF SSRSEPVNPG MHSSSHQQQD GDAAMHGAHM DSPVRYTPYT ISPYNRKGSF RKQDQTHVNM EREQKPPERR MEGNMPDGTL GSWFKITVPF GIKYNEKWLL NL

Highest antigen sequence identity to orthologs:

• Mouse: 38%
• Rat: 39%

Target Information

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), four leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins.
The LRRs and NTF2-like domains are required for export activity. Alternative splicing is a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RBD is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.