Thermo Fisher Scientific SKAP2 Polyclonal Antibody
SKAP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol 버퍼에 보존. 인체 반응성, 연구용 전용 시약.
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Thermo Fisher Scientific SKAP2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 296–359 of SCAP2 (Uniprot ID: O75563) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154020 |
Product Specific Information
- Recommended positive control: HepG2
- Predicted reactivity: Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R associate with the tyrosine kinase p59fyn.
SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and serve as substrates for p59Fyn in resting T cells.
SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif (RKxxYxxY).
SKAP55-R, similar in structure, has a coiled-coil N-terminal domain.
SKAP55 associates with SLAP-130, part of the Fyn complex, regulating signaling events leading to T cell activation.
The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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