Thermo Fisher Scientific Androgen Receptor Polyclonal Antibody
Rabbit 폴리클로날 안드로겐 수용체 항체로 Western blot, IHC, IP 등 다양한 응용에 적합. 인간 AR의 1–50번 잔기 영역을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, 4°C 보관. 마우스, 랫, 돼지 등과 교차 반응 예측.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of human Androgen Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Predicted to react with Mouse, Rat, Dog, Pig, Monkey, and Chimpanzee (based on 100% sequence identity)
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon hormone binding, the receptor translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling is essential for male reproductive organ development and function and also affects nonreproductive tissues such as muscle, hair follicles, and brain. The receptor is a phosphoprotein that regulates MAP kinase activity, and its phosphorylation state correlates with MEK1/2 pathway inhibition. Dysregulation of AR signaling is associated with diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations in AR can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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