Thermo Fisher Scientific CBF beta Polyclonal Antibody
Thermo Fisher Scientific의 CBF beta Polyclonal Antibody는 인간 단백질에 특이적인 토끼 다클론 항체로 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 다양한 종에 예측 반응성을 보입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA528505
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–182 of Human PEBP2beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545981 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (85%), Xenopus laevis (92%), Cat (100%), Chicken (96%), Rhesus Monkey (97%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family, which regulates genes involved in hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit acts as a non-DNA binding regulatory subunit that enhances DNA binding by the alpha subunit.
Alternative splicing generates two mRNA variants encoding distinct isoforms.
A chromosomal rearrangement [inv(16)(p13q22)] that fuses this gene with MYH11 is associated with acute myeloid leukemia (M4Eo subtype).
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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