Thermo Fisher Scientific SIGLEC12 Polyclonal Antibody
Human SIGLEC12 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 IHC(Paraffin)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA531457
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 133–404 of Human SIGLEC12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.99 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2548931 |
Product Specific Information
- Recommended positive controls: MCF-7
- Predicted reactivity: Chimpanzee (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to sialic acid moieties on glycolipids and glycoproteins.
SIGLEC12 encodes a member of the SIGLEC3-like subfamily characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set domains and cytoplasmic tyrosine-based motifs (ITIM and SLAM-like). Upon tyrosine phosphorylation, the protein recruits SHP1 and SHP2 phosphatases and may function as an inhibitory receptor involved in negative regulation of macrophage signaling.
This gene is located on chromosome 19q13.4 in a cluster with other SIGLEC3-like genes. Alternatively spliced transcript variants encoding distinct isoforms have been described.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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