Thermo Fisher Scientific LNX1 Polyclonal Antibody
LNX1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, Human 시료에 반응. Protein A 정제, PBS+2% sucrose buffer, -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human LNX1 (aa 527–576) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2606472 |
Product Specific Information
Peptide sequence:
SHREWDLPIY VISVEPGGVI SRDGRIKTGD ILLNVDGVEL TEVSRSEAVA
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 93%
Horse: 100%
Human: 100%
Mouse: 100%
Pig: 100%
Rabbit: 100%
Rat: 100%
Target Information
LNX1 (Ligand of Numb Protein X 1) protein is encoded by the LNX1 gene located on chromosome 4 in humans and is also known as PDZRN2 (PDZ domain-containing RING finger 2). Through its RING finger and PDZ domains, LNX1 forms oligomers and interacts with target proteins such as JAM4 to form multiprotein complexes. LNX1 functions as an E3 ubiquitin ligase containing NPXY motifs that bind to the phosphotyrosine-binding (PTB) domain on Numb protein. This interaction mediates ubiquitination of Numb, preventing proteasomal degradation of the Notch intracellular domain (NICD), thereby positively regulating the Notch signaling pathway.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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