Thermo Fisher Scientific TRAF7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.2-1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the N-terminal of human TRAF7 (aa 35-84). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRAF7,uniProtId:Q6Q0C0-1,ncbiNodeId:9606,antigenRange:35-84,antigenLength:670,antigenImageFileName:PA5-42346_TRAF7_Q6Q0C0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-42346_TRAF7_Q6Q0C0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2607222

Product Specific Information

Peptide sequence: GPAFSAVTTI TKADGTSTYK QHCRTPSSSS TLAYSPRDEE DSMPPISTPR

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 100%

Target Information

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.