Thermo Fisher Scientific TRAF7 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: GPAFSAVTTI TKADGTSTYK QHCRTPSSSS TLAYSPRDEE DSMPPISTPR
• Sequence homology:
  • Cow: 100%
  • Dog: 100%
  • Guinea Pig: 93%
  • Horse: 100%
  • Human: 100%
  • Mouse: 93%
  • Pig: 100%
  • Rat: 100%

Target Information

TRAFs are signal transducers for members of the TNFR superfamily, critically involved in activation of MAP3K family members in NF-κB and JNK signaling and apoptosis.
TRAF7, a novel 670 amino acid protein, is the human homolog of mouse Traf7 and consists of:

• N-terminal RING finger domain
• Central TRAF domain
• Coiled-coil motif
• Seven WD40 repeats at the C-terminus

It has E3-ubiquitin ligase activity for self-ubiquitination and specifically interacts with MEKK3 to mediate MEKK3-induced AP1 and CHOP activation, inducing apoptosis through Caspase-independent pathways.
TRAF7 is multifunctional, involved in sumoylation and negative regulation of c-Myb, thereby modulating proliferation and differentiation of hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.