Thermo Fisher Scientific SRSF4 Polyclonal Antibody
SRSF4 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에서 사용 가능. Western blot과 Immunocytochemistry에 적합하며 고순도의 affinity chromatography로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SRSF4 (Accession Q08170), corresponding to amino acid residues R114–E164 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850592 |
Product Specific Information
Antibody detects endogenous levels of total SFRS4.
Target Information
Serine/arginine-rich protein 75 (SRp75) is encoded by the SRSF4 gene. SRp75 belongs to the arginine/serine-rich factor family and likely plays a role in alternative mRNA splicing.
The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/serine (RS)-rich domain. They are essential for constitutive splicing and regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites.
Most SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 shuttle between the nucleus and cytoplasm, contributing to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by hnRNP A/B family proteins, which can induce shifts in splice site selection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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