Thermo Fisher Scientific TNFSF18 Monoclonal Antibody (4D10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:

QLETAKEPCM AKFGPLPSKW QMASSEPPCV NKVSDWKLEI LQNGLYLIYG QVAPNANYND VAPFEVRLYK NKDMIQTLTN KSKIQNVGGT YELHVGDTID LIFNSEHQVL KNNTYWGIIL LANPQFIS

Target Information

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through the activation of NF-kappa-B and various mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is expressed on CD4+ CD25+ regulatory T cells and plays crucial roles in immune regulation.
Its ligand, GITRL, is expressed in endothelial and antigen-presenting cells, capable of activating NF-kappa-B, inducing both pro- and anti-apoptotic effects, inhibiting Treg suppressive activity, and co-stimulating responder T cells via GITR.
Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, indicating that the GITRL–GITR pathway involves both NIK and TRAF2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.