Thermo Fisher Scientific TNFSF18 Monoclonal Antibody (3D12)
인간 TNFSF18(GITRL)을 인식하는 Mouse IgG1 단클론 항체입니다. ELISA에 적합하며, 액상 형태로 제공됩니다. PBS(pH 7.2) 버퍼에 보존제 없이 보관하며, -20°C에서 보관 권장됩니다. 세포 신호 조절 연구용으로 사용됩니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D12 |
| Immunogen | Recombinant Flag/His fusion protein corresponding to amino acids 50–177 of human TNFSF18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through activation of NF-kappa-B and various mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is expressed on CD4+ CD25+ regulatory T cells and plays a crucial role in immune regulation. Its ligand GITRL, expressed in endothelial and antigen-presenting cells, can activate NF-kappa-B, induce both pro- and anti-apoptotic effects, inhibit suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR.
Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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