Thermo Fisher Scientific Fibulin 1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Fibulin 1. Recombinant protein control fragment (Product #RP-100521). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Fibulin 1,uniProtId:P23142-1,ncbiNodeId:9606,antigenRange:266-402,antigenLength:703,antigenImageFileName:PA5-51612_Fibulin_1_P23142-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51612_Fibulin_1_P23142-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641630

Product Specific Information

Immunogen sequence: CESGIHNCLP DFICQNTLGS FRCRPKLQCK SGFIQDALGN CIDINECLSI SAPCPIGHTC INTEGSYTCQ KNVPNCGRGY HLNEEGTRCV DVDECAPPAE PCGKGHRCVN SPGSFRCECK TGYYFDGISR MCVDVNE

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

Target Information

Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.