Thermo Fisher Scientific MREG Polyclonal Antibody
Thermo Fisher Scientific의 MREG Polyclonal Antibody는 인간 MREG 단백질의 C-말단 합성 펩타이드를 면역원으로 제작된 토끼 다클론 항체입니다. 웨스턴 블롯에 최적화되어 있으며, 다양한 종에서 높은 상동성을 보입니다. 액상 형태로 제공되며 -20°C에서 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of human MREG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690255 |
Product Specific Information
This target displays homology in the following species:
- Cow: 100%
- Dog: 100%
- Guinea Pig: 93%
- Horse: 100%
- Human: 100%
- Mouse: 93%
- Rabbit: 93%
- Rat: 100%
Target Information
MREG probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery.
It plays a role in hair pigmentation by mediating melanosome transport between melanocytes and keratinocytes.
Functions as a receptor for RILP and DCTN1 complexes on melanosomes, contributing to retrograde transport.
Overexpression leads to accumulation of late endosomes/lysosomes at the microtubule organizing center (MTOC).
Binds cholesterol and specific phosphatidylinositol phosphates, required for microtubule-mediated organelle transport.
Essential for normal phagosome clearance and lysosomal enzyme activation in retinal pigment epithelium cells (PubMed:19240024).
Involved in degradation of A2E in the eye and may regulate membrane fusion and photoreceptor disk biogenesis.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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