Thermo Fisher Scientific DGKD Polyclonal Antibody

Applications

• Western Blot (WB): Tested at 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 79%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%

Target Information

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid act as second messengers in signaling cascades.
DGK-alpha influences cell activation and secretion of lethal exosomes, which control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts expressed in various human tissues, with greatest expression in retina. DGK-delta is most abundant in skeletal muscle. DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript (>12 kb). DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle.
DGKs have structural motifs that play regulatory roles, forming the basis for dividing DGKs into five subtypes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.