Thermo Fisher Scientific BAP1 Polyclonal Antibody
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA5110967 | - | Thermo Fisher Scientific PA5110967 BAP1 Polyclonal Antibody 100 ul pk | 재고문의 | pk | 775,000원 | - | 852,500원 | |
PA5111420 | - | Thermo Fisher Scientific PA5111420 BAP1 Polyclonal Antibody 100 ul pk | 재고문의 | pk | 775,000원 | - | 852,500원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Immunocytochemistry (ICC/IF)
0.25-2 µg/mL
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human BAP1. Recombinant protein control fragment (Product #RP-105797). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
BAP1,
uniProtId:
Q92560-1,
ncbiNodeId:
9606,
antigenRange:
625-715,
antigenLength:
729,
antigenImageFileName:
PA5-110967_BAP1_Q92560-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-110967_BAP1_Q92560-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856378
Product Specific Information
Immunogen sequence: EKYSPKELLA LLKCVEAEIA NYEACLKEEV EKRKKFKIDD QRRTHNYDEF ICTFISMLAQ EGMLANLVEQ NISVRRRQGV SIGRLHKQRK P
Target Information
BRCA1-associated protein-1, or BAP1, interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4. 8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21. 3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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