Thermo Fisher Scientific CD317 (BST2, PDCA-1) Monoclonal Antibody (eBio927), PE, eBioscience
PDCA-1(BST2, CD317)을 인식하는 eBio927 단클론 항체로, 생쥐 pDC 분석에 최적화된 PE 형광 접합 제품입니다. Flow cytometry에 적합하며, 0.25 µg/test로 사용 가능합니다. 565/576 nm의 Excitation/Emission 특성을 가지며, 다양한 형광 포맷으로 제공됩니다.
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Thermo Fisher Scientific CD317 (BST2, PDCA-1) Monoclonal Antibody (eBio927), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.25 µg/test
Publications: View 11 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Recommended Isotype Control | Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio927 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_763421 |
Additional Formats
- Alexa Fluor 488
- APC
- Biotin
- eFluor 450
- FITC
- Functional Grade
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
The eBio927 monoclonal antibody reacts with PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naive mouse.
Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in naive mice (<0.5% of splenocytes) and is upregulated following IFN stimulation.
PDCA-1 cycles between cell surface and intracellular compartments and may regulate cytokine trafficking. It is the same protein recognized by antibody 120G8.
The eBio927 antibody shows functional activity; its epitope differs from eBio129c, enabling costaining and purification of pDCs.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on SJL splenocytes; ≤0.25 µg/test (100 µL final volume, 10⁵–10⁸ cells/test). Optimize titration per assay.
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in B-cell development and growth.
BST2 expression supports stromal cell-dependent growth of pre-B-cell lines and is found in B-cells, T-cells, monocytes, NK cells, dendritic cells, and myeloma cells.
It functions as an inhibitor of retrovirus release from human cells, antagonized by HIV-1 Vpu. BST2 retention of virions may represent a therapeutic target for HIV/AIDS.
BST2 dysfunction is also associated with stomatitis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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