Thermo Fisher Scientific ITGB1 Monoclonal Antibody (4B7R), PE

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store product undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
• Mouse anti-human CD29 monoclonal antibody (clone 4B7R) recognizes the human integrin beta 1 subunit (CD29), a ~130 kDa (red) / 115 kDa (non-red) single-pass type I transmembrane glycoprotein expressed by most leukocytes and mesenchymal stem cells.

Target Information

ITGB1 (Integrin Subunit Beta 1, CD29)

• 110 kDa cell surface glycoprotein expressed by various cells including all leukocytes.
• Forms non-covalent heterodimers with at least six alpha chains (α1–α6), determining the binding properties of β1 (VLA) integrins.
• Functions as a cell adhesion molecule on platelets and in complexes binding extracellular matrix proteins.
• Decreased expression correlates with multidrug resistance in tumor cells.
• Upregulated during leukocyte migration and involved in immune cell trafficking.
• Regulates tissue damage and inflammatory responses, including in inflammatory bowel disease.
• Involved in cytokine secretion regulation via fibronectin and type I collagen in airway smooth muscle.
• Two major isoforms: β1A (ubiquitous) and β1D (cardiac and skeletal muscle).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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