Thermo Fisher Scientific p600 Polyclonal Antibody
Thermo Fisher Scientific의 p600 Polyclonal Antibody는 Human UBR4 단백질을 인식하는 Rabbit IgG 기반 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 5133 and 5183 of human retinoblastoma-associated factor 600 (UBR4, UniProt ID: Q5T4S7-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on sequence identity, predicted to react with Mouse and Rat
Target Information
E3 ubiquitin-protein ligase that functions in the N-end rule pathway. Recognizes and binds to proteins with destabilizing N-terminal residues, leading to ubiquitination and degradation. Forms meshwork structures with clathrin for membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling and may activate FAK in response to cell-matrix interactions. Mediates ubiquitination and degradation of ACLY.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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