Thermo Fisher Scientific KIR2DS2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• Publications: References

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, found in a cluster on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
KIR proteins are classified by:

• Number of extracellular immunoglobulin domains (2D or 3D)
• Length of cytoplasmic domain (L or S)

KIR proteins with long cytoplasmic domains transduce inhibitory signals via ITIM motifs, while those with short domains associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
Ligands for several KIR proteins are subsets of HLA class I molecules, contributing to immune response regulation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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