Thermo Fisher Scientific KIR2DS2 Polyclonal Antibody
인간 KIR2DS2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공. 4°C 단기, -20°C 장기 보관 권장. 연구용으로만 사용.
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Thermo Fisher Scientific KIR2DS2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–260 of Human KIR2DS2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2548938 |
Product Specific Information
- Recommended positive controls: 293T, A431, Jurkat, Raji
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, located in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
KIR proteins are classified by:
- Number of extracellular immunoglobulin domains (2D or 3D)
- Length of cytoplasmic domain (L: long, S: short)
KIR proteins with long cytoplasmic domains transduce inhibitory signals via ITIM motifs, while those with short domains lack ITIM and associate with TYRO protein tyrosine kinase binding protein to transduce activating signals. Ligands for several KIR proteins are subsets of HLA class I molecules, playing a key role in immune regulation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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