Thermo Fisher Scientific Human BCAR3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to a 16 amino acid sequence near the amino terminus of human BCAR3.
PEP-1467 can be used as a blocking peptide with polyclonal antibody PA5-34425.

Target Information

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers may progress to become anti-estrogen resistant.
Breast cancer anti-estrogen resistance gene 3 (BCAR3) was identified in the search for genes involved in the development of estrogen resistance.
The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells.
The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.