Thermo Fisher Scientific Human SCUBE3 Synthetic Peptide
Human SCUBE3 단백질의 중심부 15개 아미노산 서열로 구성된 합성 펩타이드. PA5-34427 항체의 블로킹 펩타이드로 사용 가능. PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide 함유. -20°C에서 보관. 연구용으로만 사용.
- 카탈로그번호
- PEP1469
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to a 15 amino acid sequence near the center of human SCUBE3.
PEP-1469 can be used as a blocking peptide with the polyclonal antibody PA5-34427.
Target Information
SCUBE3 is a member of a family of secreted glycoproteins containing N-terminal EGF-like repeats, C-terminal cysteine-rich motifs, and a CUB domain. It is highly expressed in primary osteoblasts and bones, and to a lesser extent in the heart.
Overexpression of SCUBE3 in mice has been shown to induce cardiac hypertrophy, suggesting a role in cardiac growth regulation. SCUBE3 functions as an endogenous TGF-Beta receptor ligand and may promote lung cancer cell mobility and invasiveness. In lung cancer cells, SCUBE3 is cleaved by MMP2 and MMP9, activating the TGF-Beta receptor, increasing Smad2/3 transcriptional activity, and upregulating proteins such as TGF-Beta1, VEGF, Snail, and Slug.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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