Thermo Fisher Scientific PLCG1 Recombinant Rabbit Monoclonal Antibody (ARC1345)
PLCG1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 HEK293 세포에서 발현되었습니다. 고순도의 액상 항체로 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:4,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1345 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 710–832 of human PLC gamma 1 (PLCG1) (P19174) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849632 |
Product Specific Information
Immunogen sequence:
GKIKHCRVQQ EGQTVMLGNS EFDSLVDLIS YYEKHPLYRK MKLRYPINEE ALEKIGTAEP DYGALYEGRN PGFYVEANPM PTFKCAVKAL FDYKAQREDE LTFIKSAIIQ NVEKQEGGWW RGD
Target Information
The mammalian Phospholipase Cγ (PLCγ) family includes two closely related proteins, PLCγ1 and PLCγ2. These isozymes share core structural domains and contain an additional PH domain, two SH2 domains, and one SH3 domain.
In response to extracellular stimuli such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCγ. Activated PLCγ catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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