Thermo Fisher Scientific TCF7 Recombinant Rabbit Monoclonal Antibody (18H15L9)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

ChIP assay (ChIP)

• Tested Dilution: 2 µg/million cells

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, and Bovine.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

TCF7 (Transcriptional Factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. It is necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene and may act as a feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1–TLE4 repress transactivation mediated by TCF7 and CTNNB1.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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