Thermo Fisher Scientific TCF7 Recombinant Rabbit Monoclonal Antibody (18H15L9)
TCF7 단백질을 인식하는 재조합 토끼 단일클론 항체로, ICC/IF 및 ChIP 분석에 적합. 높은 특이성과 일관된 로트 간 품질을 제공하며, 인간 및 유사 종에 반응. 동물 유래 성분이 없는 포뮬레이션으로 연구용에 최적화.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
ChIP assay (ChIP)
- Tested Dilution: 2 µg/million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 18H15L9 |
| Immunogen | Protein corresponding to human TCF7 [aa1–aa384] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784552 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
TCF7 (Transcriptional Factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. It is necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene and may act as a feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1–TLE4 repress transactivation mediated by TCF7 and CTNNB1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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