Thermo Fisher Scientific LARP1 Polyclonal Antibody
인간 LARP1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, IHC 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관. mTORC1 경로 관련 단백질 번역 조절 연구에 활용 가능.
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Thermo Fisher Scientific LARP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 575 and 625 of human La ribonucleoprotein domain family, member 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, depending on growth signals and nutrient availability.
Interacts with both the 3′ poly-A tails of mRNA molecules and the 7-methylguanosine cap structure of mRNAs containing a 5′TOP motif, which are involved in ribosomal protein synthesis.
Under normal nutrient conditions, LARP1 associates with ribosomes and promotes translation of 5′TOP motif-containing mRNAs, thereby regulating protein synthesis, cell growth, and proliferation.
Phosphorylation by mTORC1 modulates its binding to mRNA and translation activity.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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