Thermo Fisher Scientific PICK1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
IEEDKLGIPTV PGKVTLQKDA QNLIGISIGG GAQYCPCLYI VQVFDNTPAA LDGTVAAGDE ITGVNGRSIK GKTKVEVAKM IQEVKGEVTI HYNKLQADPK QGMSLDIVLK KVKHRLVENM SSGTADALGL SRAILCNDGL VKRLEELERTA

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 99%
  • Rat: 100%

Target Information

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCα), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCα is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCα to membrane-anchored GluR2. Once phosphorylated by PKCα, GluR2 is released from the synaptic anchor proteins and transported from the synaptic membrane in a PICK1-dependent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.