Thermo Fisher Scientific AXL Monoclonal Antibody (6C8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
TQAEESPFVG NPGNITGARG LTGTLRCQLQ VQGEPPEVHW LRDGQILELA DSTQTQVPLG EDEQDDWIVV SQLRITSLQL SDTGQYQCLV FLGHQTFVSQ PGYVGLEGLP Y

Target Information

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma.
The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation.

TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors show degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad-spectrum auto-antibodies.

Axl may also function as a putative entry receptor for filoviruses and is used to identify a specific subpopulation of human blood dendritic cells (Siglec 6+/Axl+). Cellular expression of Axl can be upregulated by TLR ligands such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form, and increased plasma levels may be indicative of inflammation and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.