Thermo Fisher Scientific P16INK4a Recombinant Rabbit Monoclonal Antibody (CDKN2A/7081R)
p16INK4a 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot 및 IHC 분석에 적합하며, 인간 시료에 반응. Protein A/G로 정제된 액상 형태로 제공되며, 보존제가 포함되지 않음. 세포주기 조절 및 종양 억제 연구에 활용 가능.
- 카탈로그번호
- 1029-RBM7-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CDKN2A/7081R |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode isoforms functioning as inhibitors of CDK4 kinase. Another transcript includes an alternate first exon located 20 Kb upstream, encoding a structurally unrelated ARF protein that stabilizes tumor suppressor p53 by interacting with and sequestering MDM2. Despite structural and functional differences, both CDK inhibitor isoforms and ARF share a common role in cell cycle G1 control via CDK4 and p53 regulation. This gene is frequently mutated or deleted in various tumors and is recognized as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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