Thermo Fisher Scientific PI3K p85/p55 Polyclonal Antibody
PI3K p85/p55 단백질을 인식하는 토끼 폴리클로날 항체로, Western Blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 완충액에 보관하며, 연구용으로만 사용됩니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 400–500 of human PIK3R1/PIK3R2/PIK3R3 (NP_8526641) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2901454 |
Product Specific Information
Positive Samples: Jukat, NIH/3T3, Mouse brain, Rat brain, Rat liver
Target Information
Phosphoinositide 3-kinase (PI3K, phospho PI3K) binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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