Thermo Fisher Scientific COQ10B Polyclonal Antibody
Human COQ10B 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보존. COQ10B의 미토콘드리아 및 대사 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COQ10B. Recombinant protein control fragment (Product # RP-96025) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640068 |
Product Specific Information
Immunogen sequence:
ARTGHTALRR VVSGCRPKSA TAAGAQAPVR NGRYLASCGI LMSRTLPLHT SILPKEICAR TFFKITAPLI NKRK
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 61%
- Rat: 64%
Target Information
COQ10B (Coenzyme Q10B) is a 247 amino acid mitochondrial protein encoded by the human COQ10B gene. It belongs to the COQ10 family and functions as an essential biological cofactor that increases brain mitochondrial concentration and provides neuroprotective effects.
Plasma COQ10B levels are decreased in patients with advanced chronic heart failure (CHF) and in hyperthyroid conditions, while elevated levels are observed in hypothyroid subjects, including subclinical cases. These variations suggest COQ10B as a potential biomarker for thyroid and metabolic status.
Thyroid hormones play a key role in modulating COQ10B levels, with thyroid deficiency exerting a predominant effect compared to adrenal deficiency.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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