Thermo Fisher Scientific APBB1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000
• Immunocytochemistry (ICC/IF): 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSVPSSLSQS AINANSHGGP ALSLPLPLHA AHNQLLNAKL QATAVGPKDL RSAMGEGGGP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEPEMAPLGP KGLIHLYSEL ELSAHNAANR GLRGPGLIIS TQEQGPDEGE EKAAGEAEEE EEDDDDEEEE EDLSSPPGLP EPLESVEAPP RPQALTDGPR EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL TWTGFAHGEG FEDGEFWKDE PSDEAPMELG LKEPEEGTLT FPAQSLSPEP LPQEEEKLPP RNTNPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ LSYHKNNLHD PMSGGWGEGK DLLLQLEDET LKLVEPQSQA LLHAQPIISI RVWGVGRDSG RDFAYVARDK LTQMLKCHVF RCEAPAKNIA TSLHEICSKI MAERRNARCL VNGLSLDHSK LVDVPFQVEF PAPKNELVQK FQVYYLGNVP VAKPVGVDVI NGALESVLSS SSREQWTPSH VSVAPATLTI LHQQTEAVLG ECRVRFLSFL AVGRDVHTFA FIMAAGPASF CCHMFWCEPN AASLSEAVQA ACMLRYQKCL DARSQASTSC LPAPPAESVA RRVGWTVRRG VQSLWGSLKP KRLGAHTP

Target Information

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus and interacts with the Alzheimer’s disease amyloid precursor protein, transcription factor CP2/LSF/LBP1, and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product’s nuclear translocation. This encoded protein may play an important role in the pathogenesis of Alzheimer’s disease and is thought to regulate transcription. It can block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene, though some full-length sequences are not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.