Thermo Fisher Scientific ASGR1 Polyclonal Antibody
ASGR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로서, Human, Mouse, Rat 시료에 반응합니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 고순도(>95%) 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human ASGR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804024 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on hepatocyte surfaces in a polar manner, present on sinusoidal and lateral plasma membranes but not on the bile canalicular membrane.
Mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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