Thermo Fisher Scientific OXER1 Polyclonal Antibody
OXER1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 인체 조직에서 발현 분석에 적합합니다. IHC(P) 검증 완료, 항원 친화 크로마토그래피로 정제, PBS 버퍼 및 나트륨 아지드 포함, 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from C-terminus of human OXER1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551416 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla (100%)
- Monkey (89%)
Target Information
TG1019 is a G protein-coupled receptor that functions as a chemoattractant for eosinophils and neutrophils.
It is expressed in various tissues except the brain, with the highest expression in liver, kidney, peripheral leukocyte, lung, and spleen.
TG1019 interacts with the protein OXE to form TG1019/OXE, a Galpha i/o protein-coupled receptor.
Signals from TG1019 are transduced via a Galpha i/o protein to PLC/calcium, MEK/ERK, and PI3K/Akt pathways.
Signal transduction following stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE) induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt pathways.
TG1019 may also play a role in downregulating cAMP production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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