Thermo Fisher Scientific NEFM Monoclonal Antibody (OTI2C4), TrueMAB
인간 NEFM 단백질을 인식하는 단클론 항체로, Western blot과 Immunocytochemistry에 적합합니다. TrueMAB 포맷으로 제작되었으며, 고순도의 액상 형태로 제공됩니다. 신경세포 마커 연구에 유용하며, -20°C에서 안정적으로 보관 가능합니다.
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Applications
- Western Blot (WB): 1:4,000
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C4 |
| Immunogen | Full length human recombinant protein of human NEFM produced in HEK293T cell (UniProt ID: P07197-1, Antigen range: 1–916). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Neurofilaments (NFs) are intermediate filaments expressed almost exclusively in neuronal cells, particularly in large axons. They consist of three polypeptide chains—NF-M (medium), NF-H (high), and NF-L (light)—that share a coiled-coil core domain but differ in terminal sequences. NF-M plays a crucial role in maintaining axonal size and cytoskeletal architecture through its phosphorylated tail domain. Phosphorylation and O-GlcNAcylation of NF-M are reciprocally regulated, influencing filament formation and function. Antibodies against neurofilament subunits are valuable neuronal markers due to their abundance, neuron-specific expression, and biochemical stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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